IndraLab

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"EGCG also blocks LPS induction of nitric oxide synthase in mouse macrophages, by down-regulating the LPS induced activity of the transcription factor NF-KB [8]."
12095176
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"Recently, we have found that the major tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) suppresses extracellular signals and cell proliferation through epidermal growth factor receptor binding in human A431 epidermoid carcinoma cells; EGCG also blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide induced activity of the transcription factor NFKB in macrophages."
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"Therefore, EGCG can inhibit the MAPK/ERK and PI3K/Akt signaling pathways, as well as the activation of NFkB."
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