IndraLab

Statements

USP19 activates ME1. 5 / 5
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"USP19-mediated ME1 stabilization is enhanced by phosphorylation, generating oncogenic phenotypes, and either USP19 deletion or a point mutation in ME1 protein that prevents ubiquitination, represses colorectal carcinogenesis."
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"Meanwhile, depletion of USP19 significantly reduced ME1 protein half-life in CRC cells ( Figures 1 D, 1E, and S1 F)."
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"These findings suggest that USP19 promotes the stability of ME1 through direct interaction and deubiquitination.The foregoing results indicate that USP19 deubiquinates ME1, but whether E3 ubiquitin li[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Ubiquitin-specific peptidase 19 (USP19) antagonizes ring finger protein 1 (RNF1)-mediated ME1 degradation by deubiquitination, thereby promoting lipid metabolism and NADPH production, and suppressing ROS, thereby promoting colorectal carcinogenesis [141]."
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"In addition, USP19 antagonizes ring finger protein 1 (RPF1)-mediated malic enzyme 1 (ME1) degradation through deubiquitination, which in turn promotes lipid metabolism associated with ERK2 activity and CRC development in human patients [139]."
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