IndraLab

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UCHL1 inhibits cell growth. 9 / 10
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"25 The conclusion from these data was that UCH-L1 is an inhibitor of tumor cell growth."
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"Our results have shown that UCHL1 inhibited LNCaP cell growth."
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"Our loss of function studies using these pediatric high-grade gliomas cell lines showed that UCHL1 promoted cell growth, invasiveness, and self-renewal characteristics in vitro."
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"Ectopic UCHL1 expression in breast tumor cells suppresses cell growth and induces G0/G1 arrest and apoptosis through p53 signaling due to its DUB activity [39]."
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"Our results have shown that UCHL1 inhibited LNCaP cell growth."
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"Furthermore, UCHL1 knockdown in ovarian cancer cell lines A2780 and IGROV1 promoted cell growth while causing reduction of apoptosis."
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"Ectopic UCHL1 expression in breast tumor cells suppresses cell growth, induces G0/G1 arrest and apoptosis through disrupting p53 signaling, depending on its deubiquitinase (DUB) activity, suggesting that UCHL1 is a functional tumor suppressor and potential tumor marker for this cancer."
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"As shown in XREF_FIG, elevated UCH-L1 expression in MCF7 cells suppressed cell growth, while knockdown of UCH-L1 in MCF7 and Adr cells led to the opposite effect when compared with negative controls."
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"Moreover, UCHL1 knockdown in ovarian cancer cell lines had increased cell growth, decreased apoptosis, and increased cisplatin resistance [43]."
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