IndraLab

Statements

ACVRL1 binds USP15. 5 / 5
2 | 1 2
reach
"On further exploration, we found that knockdown of USP15 did not affect the interaction between ACVRL1 and GPX2 (Additional file 1: Figure S3C); similarly, knockdown of GPX2 also did not affect the interaction between ACVRL1 and USP15 (Additional file 1: Figure S3D), which indicated that ACVRL1 can directly interact with both GPX2 and USP15 independently."
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sparser
"On further exploration, we found that knockdown of USP15 did not affect the interaction between ACVRL1 and GPX2 (Additional file xref : Figure S3C); similarly, knockdown of GPX2 also did not affect the interaction between ACVRL1 and USP15 (Additional file xref : Figure S3D), which indicated that ACVRL1 can directly interact with both GPX2 and USP15 independently."
37743483
sparser
"Our previous research demonstrated that USP15 interacts with ACVRL1 to deubiquitinate GPX2 at the K187 site, leading to GPX2 accumulation and enhanced resistance of colorectal cancer cells to multitargeted tyrosine kinase inhibitors such as regorafenib and sorafenib ( xref )."
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biogrid
No evidence text available
37743483
biogrid
No evidence text available
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