IndraLab

Statements

USP15 binds USP4 and SART3. 6 / 6
| 1 5
reach
"Deubiquitination of PRP31 and PRP3 by the USP15, SART3, and USP4 complex decreases the affinity towards PRP8 and this regulation is important for the proper splicing of chromosome segregation related genes such as Bub1 and alpha-tubulin."
28088760
sparser
"PRP31, a component of the U4 snRNP, is modified with K63-linked ubiquitin chains by the PRP19 complex and is deubiquitinated by the ternary complex of USP15, SART3, and USP4."
32377397
sparser
"Consistent with our prediction, SART3 interacted with endogenous USP4 and USP15 (Figure xref )."
28088760
sparser
"We next examined whether SART3 forms a complex with USP15 and USP4 simultaneously using sequential immunoprecipitation."
28088760
sparser
"Moreover, as a substrate recruiting factor of USP15 either ( xref ; xref ), SART3 can simultaneously bind USP4 and USP15, serving as a platform to deubiquitinate PRP31 and PRP3 ( xref )."
33681193
sparser
"Drugs interfering with the interaction between USP4 and USP15 and SART3 may selectively inhibit the DUB functions in the nucleus."
| PMC