IndraLab

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Acetylcholine inhibits STAT1. 3 / 3

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"Furthermore, Ach decreases ISGylation of STAT1 (protein conjugation of a small ubiquitin like modifier, ISG15, Western blot), which preserves STAT1 activation."

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"In addition, Ach decreased accumulation of pSTAT1 in the nuclear fraction."

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"The mechanism by which Ach down-regulates pSTAT1 is related to an enhanced interaction between IFNalphaR2 and USP18 that finally dysregulates the cross talk between the IFN receptor on the cell surface and STAT1."

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IndraLab

Statements

Acetylcholine inhibits STAT1. 3 / 3

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