IndraLab

Statements

SB-202190 inhibits MAPK8. 5 / 6
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"SCH772984, SB202190, and BI-78D3, which are inhibitors of p-ERK, p-P38, and p-JNK, were found to enhance the protective effect of ICA against OGD-induced ERs, as well as the down regulation of MAPK si[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As expected, 20 μM SB202190 and 30 μM SP600125 profoundly inhibited TCDD induced up-regulation of p-p38 and p-JNK, respectively."
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"Treatment with a JNK pathway inhibitor, SB202190 (10–20 μ m ), almost abolished the hyperosmolarity induced activation of JNK-1 and JNK-2."
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"As shown in Fig. 4 A, the Western blot clearly demonstrates that the addition of 20 μM of SB202190 almost abolished the activation of JNK-1 and JNK-2 by hyperosmolar media (500 mOsM)."
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"SB202190 abolished this activation of JNK1 ( P <0.05, n =3) while doxycycline and dexamethasone showed little inhibitory effects ( P >0.05, n =3, Fig. 4 A)."
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