IndraLab

Statements

Catenin binds USP2. 6 / 6
| 6
sparser
"However, inhibiting the Wnt /β‐catenin canonical pathway and down‐regulating β‐catenin can achieve the aim of improving the ventricular remodelling. xref Actually, one of the major mechanisms of β‐catenin regulation is ubiquitination, beside which DUBs, such as USP47, USP20, and USP2, have also been shown to deubiquitinate and stabilize β‐catenin directly. xref , xref , xref In this study, β‐catenin was down‐regulated by USP2 inhibition, which prompted us to assess the interaction between USP2 and β‐catenin."
33314748
sparser
"As expected, USP2 interacted with β‐catenin, and regulated its ubiquitination and degradation in CFs."
33314748
sparser
"Furthermore, USP2 interacted with β‐catenin, thereby regulating its deubiquitination and stabilization in CFs."
33314748
sparser
"To further detect the interaction between β‐catenin and USP2, Co‐IP was performed."
33314748
sparser
"To investigate the potential interaction between β‐catenin and USP2, co‐immunoprecipitation (Co‐IP) was performed."
33314748
sparser
"As expected, we found that USP2 notably interacted with β‐catenin in CFs (Figure xref )."
33314748