IndraLab

Statements

Estrogen inhibits JUN. 3 / 3
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"Estrogen deficiency promotes cell differentiation of osteoclast progenitors by suppressing c-Jun activity."
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"Under normal conditions these estrogen responsive cells are growth inhibited by this agent and medroxyprogesterone acetate decreases c-jun ex- pression and endogenous AP-1 activity."
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"Estrogen inhibits the activity of c-Jun, a protein involved in osteoclast precursor cell differentiation induced by RANKL, as well as basal c-Jun N-terminal kinase activity, thereby exerting a direct inhibitory effect on osteoclasts [182]."
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