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Cortisol inhibits STAT1. 3 / 3
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"In our pulmonary endothelial cell cultures, we observed that, the use of hydrocortisone for one day reduced the mRNA synthesis of IRF9 and STAT1 -the components of the ISGF3 complex.The effect was not due to the downregulation of IFN alpha/beta receptor."
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"In addition, hydrocortisone treatment decreased IRF9 and STAT1 mRNA synthesis when measured by qPCR, which was also seen at the protein level in Fig."
32430515
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"In addition, hydrocortisone treatment decreased IRF9 and STAT1 mRNA synthesis when measured by qPCR (Fig. 1f ) , which was also seen at the protein level in Fig. 1d ."
32430515