IndraLab

Statements

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"UCH-L3 was found to be downregulated in the highly metastatic prostate cell lines, and knockdown of UCH-L3 induced EMT process."
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"The reverse of the EMT event caused by UCH-L3 overexpression in PC3 coincided with a decrease of cell migration and invasion.UCH-L3 and UCH-L1 are very close relatives with high amino acid identity an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in Fig. 2 B, knockdown of UCH-L3 induces the molecular alterations of EMT."
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"These results indicate that UCH-L3 inhibits EMT by repression of EMT promoting genes such as Snail, Slug, Twist, and MMPs in normal prostate cell lines.In our previous report, we found that UCH-L1 exp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We found that knockdown of UCH-L3 induced EMT process."
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"In our study, ablation of the UCH-L3 deubiquitinating activity did not inhibit EMT and it did not reduce cancer cell migration and invasion in PC3."
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"The induction of EMT by UCH-L3 knockdown results in an increase of cell migration and invasion."
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"Contrarily, overexpression of UCH-L3 in the highly metastatic prostate cell line PC3 reverses EMT depending on the deubiquitinating activity of UCH-L3."
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"Yet, to the contrary, overexpression of UCH-L3 in highly metastatic prostate cancer cell line PC3 reverses EMT but the active site mutant UCH-L3 did not."
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"By contrast , UCHL3 is reduced in metastatic prostate cancer cell lines , and knockdown of UCHL3 promotes epithelial-to-mesenchymal transition ( EMT ) , contributing to cancer cell invasion and metastasis ( 102 ) ."
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"On the other hand, UCH-L3 inhibited EMT and had the opposite effect of UCH-L1.The view that UCH-L1 and UCH-L3 regulate EMT suggests that these two DUBs might also be associated with the regulatory mechanism of the CSC-like characteristics in prostate cancer cells."
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"These results indicate that UCH-L3 inhibits EMT by repression of EMT promoting genes such as Snail , Slug , Twist , and MMPs in normal prostate cell lines."
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