IndraLab

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IRF3/7 activates OTUD4. 2 / 2

| 2

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"Degradative ubiquitination is counteracted by DUBs, as shown for ovarian tumor family deubiquitinase 4 (OTUD4), whose expression is increased by IRF3/7 in a positive-feedback loop (Liuyu et al., 2019)."

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reach

"Viral infection leads to the IRF3/7 dependent upregulation of OTUD4 which interacts with MAVS to remove K48 linked polyubiquitin chains, thereby maintaining MAVS stability and promoting innate antiviral signaling."

30410068

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IndraLab

Statements

IRF3/7 activates OTUD4. 2 / 2

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