IndraLab

Statements

MAP3K7 binds USP18. 19 / 23
5 | 9 5
reach
"We next examined whether USP18 interacted with TAK1."
23825189
reach
"USP18 binds and deubiquitinates TAK1 to attenuate hepatic steatosis and insulin resistance in non-alcoholic liver disease (37)."
37304282
sparser
"However, NEMO deficiency did not lead to loss of interaction between USP18 and TAK1 ( xref ), suggesting that USP18 targets TAK1 complex and IKK complex by distinct mechanisms."
26240016
sparser
"In terms of mechanism, we screened some targets of USP18 in mouse primary HSCs and found that USP18 could directly bind to TAK1."
39236989
sparser
"Moreover, USP18 also binds to and deubiquitinates TAK1, thereby promoting hepatic inflammatory responses ( xref – xref )."
38322269
reach
"Interestingly, in transfection experiments, Usp18 bound to and deubiquitinated Tak1, thereby reducing its kinase activity and the associated downstream signaling."
29685903
biogrid
No evidence text available
28718215
reach
"Mechanistically, USP18 interacts with the TAK1-TAB1 complex and deubiquitinates TAK1, thereby restricting TCR-mediated NF-κB and NFAT activation, and subsequent expression of IL-2."
31078284
biogrid
No evidence text available
28718215
biogrid
No evidence text available
23825189
reach
"However, NEMO deficiency did not lead to loss of interaction between USP18 and TAK1 (XREF_FIG), suggesting that USP18 targets TAK1 complex and IKK complex by distinct mechanisms."
26240016
reach
"USP4 and USP18 bind with TAK1 and de-ubiquitinate TAK1 to inhibit its activation [10, 12]."
39033101
biogrid
No evidence text available
33051403
reach
"Moreover, USP18 also binds to and deubiquitinates TAK1, thereby promoting hepatic inflammatory responses (90–92)."
38322269
sparser
"The mechanism is that USP18 interacted with transforming growth factor-β-activated kinase 1 (TAK1) and induced its deubiquitination, thereby inhibiting TAK1-p38/c-Jun N-terminal kinase 1/2 (JNK1/2) signaling, inhibiting cardiac fibrosis xref ."
39653114
biogrid
No evidence text available
26240016
reach
"In terms of mechanism, we screened some targets of USP18 in mouse primary HSCs and found that USP18 could directly bind to TAK1."
39236989
reach
"The results indicated that USP18 interacted with TAK1, TAB1, and TAB2 without stimulation and PMA and ion stimulation reduced but did not totally abolish their association, whereas USP18 interacted with CARMA1 weakly in unstimulated cells and PMA and ion stimulation first enhanced their interaction and then resulted in their disassociation (XREF_FIG)."
23825189
sparser
"Although USP18 mutants can still bind to ubiquitinated TAK1, it fails to cleave the polyubiquitin chains, resulting in a stable USP18-ubiquitinated-TAK1 complex."
26240016