IndraLab

Statements

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"EGCG also abrogated the nicotine induced activation of AP-1 subunits c-fos and c-jun."
23835612
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"Recently, EGCG has been shown to inhibit MAP kinase pathway and activator protein-1 (AP-1) activity in human colon cancer cells."
21827739
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"The binding of EGCG with Arg17 in the WW domain prevented the binding of c-Jun, a well-known Pin1 substrate."
21750208
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"Further experiments demonstrated that EGCG reduced the transcriptional activity of activator protein-1 (AP-1) and nuclear factor kappaB (NF-kappaB), two important nuclear transcription factors that are involved in MMP-9 expression."
15708369
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"EGCG inhibits nuclear factor-kbeta and activator protein 1 in dermal fibroblasts."
25593422
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"Furthermore, we report for the first time that EGCG blocks the activation of the pro-apoptotic proteins c-JUN, P53, and PUMA [54]; all indirect/direct players in the mitochondria depolarization, and subsequent releasing of apoptogenic proteins (e.g., cytochrome c) which ended up in the activation of CASP-3 in mutant neurons."
| PMC
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"EGCG decreased transcription activity of Jun protein after induction by UVA."
15603715
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"EGCG inhibited transcription factor AP-1, binding to DNA."
29472815
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"At the same dose range that inhibited cell transformation, EGCG and theaflavins inhibited activator protein-1 (AP-1) activation."
11216482
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"We found that EGCG (50 muM) significantly inhibited the aggregation of (i)sAPPbetaf, blocked p-TAU, increased incrementPsim, decreased oxidation of DJ-1 at residue Cys106-SH, and inhibited the activation of transcription factor c-JUN and P53, PUMA, and CASPASE-3 in mutant ChLNs compared to WT."
| PMC
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"EGCG inhibits nuclear factor-kβ and activator protein 1 in dermal fibroblasts."
25593422
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"EGCG has been shown to inhibit NF-kappaB activity, MAPK pathway, activator protein-1 (AP-1) activity, and EGFR mediated downstream signaling pathways, etc.."
21295962
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"EGCG inhibits AP-1, JNK, c-Jun and cyclinD1 which are key targets on AP-1 signal transduction pathway."
15355641
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"EGCG could also inactivate c-Jun, NF-kappaB, ERK1/2, and p38 signaling, resulting in decreased expression of MMP-2 and MMP-9 in PCa cells [XREF_BIBR]."
24375392
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"In particular, EGCG inhibited tumor promoter induced activator protein-1, signal transducers and activators of transcription, phosphatidylinositol 3-kinase/Akt, and nuclear factor-kappaB activation."
19470792
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"Reporter assays indicated that both EGCG and Poly E inhibited the transcriptional activity of the activator protein 1 (AP-1), c-fos, nuclear factor kappaB, and cyclin D1 promoters."
15814656
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"However, EGCG significantly reduced c-JUN (Figure 3A,B), P53 (Figure 3A,C), PUMA (Figure 3A,D), and CASP-3 (Figure 3A,E) in PSEN1 E280A neurons compared to treated WT ChLNs cells."
| PMC
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"EGCG caused a decreased abundance of cyclin D1 and decreased activator protein 1 or NFκB promoter activity induced by a phorbol ester in cells expressing Pin1."
29843451
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"EGCG inhibits AP-1, JNK, c-Jun and cyclinD1 which are key targets on AP-1 signal transduction pathway."
15355641
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"The binding of EGCG with Arg17 in the domain (1–39) prevented the binding of substrate c-Jun."
29843451
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"These intermediate pathways are involved in transformation, differentiation, and cell proliferation but, more importantly, EGCg also inhibited activator protein 1 (AP-1) function which has been associ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11853893