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Ivabradine hydrochloride binds HCN4. 2 / 2

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"We therefore sought to investigate details of ivabradine induced block by identifying residues involved in the binding of ivabradine to HCN4, the HCN isoform most highly expressed in the sinoatrial node."

23308150

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"Ivabradine, which binds to the open HCN4 channel XREF_BIBR, XREF_BIBR, selectively slows sinus node diastolic depolarization while leaving sympathetic activation elsewhere in the heart unopposed XREF_BIBR, XREF_BIBR."

29773827

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IndraLab

Statements

Ivabradine hydrochloride binds HCN4. 2 / 2

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