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CDK5RAP3 binds TP53 and MDM2. 4 / 4

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"LZAP binds p53 and HDM2."

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"To confirm and further examine LZAP binding to HDM2 and p53, complex formation was investigated using recombinant proteins in cell-free system."

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"These results suggested that LZAP and p53 independently bind different parts of HDM2."

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"Taken together, our results propose that LZAP binds both HDM2 and p53, and regulates p53 levels in a HDM2-dependent manner."

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IndraLab

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CDK5RAP3 binds TP53 and MDM2. 4 / 4

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