IndraLab

Statements

NADPH inhibits NLRP3. 3 / 3
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"The lysosomal NADPH oxidase appeared to be a good candidate for the source of ROS and silencing NADPH oxidase reduced NLRP3 activation by asbestos and MSU."
25879282
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"ROS scavengers or knockdown of NADPH oxidase can inhibit the NLRP3 inflammasome XREF_BIBR, XREF_BIBR."
33391509
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"Mechanical ventilation induced NLRP3 inflammasome activation (XREF_FIG), release of IL-1beta (XREF_FIG, XREF_SUPPLEMENTARY, and XREF_FIG) and IL-18 (XREF_FIG and XREF_SUPPLEMENTARY) were significantly attenuated by pretreatment of mice with a mitochondrial ROS inhibitor, but not by depletion of NADPH oxidase derived ROS."
23436933