IndraLab

Statements

Simvastatin inhibits NLRP3. 9 / 9
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"However, simvastatin combined with MCC950 or NLRP3 siRNA showed no additive effects on caspase-1 activity and the release of IL-1beta, which confirmed that simvastatin indeed inhibited the activation of NLRP3 inflammasome induced by high glucose."
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"Collectively, these results demonstrate that the statin activation of PXR inhibits the activation of NLRP3 inflammasome in response to atherogenic stimuli such as ox-LDL and TNF alpha in ECs, providing a new mechanism for the cardiovascular benefit of statins."
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"XREF_BIBR XREF_BIBR On the contrary, other research groups describe statin inhibits the formation of NLRP3 in immune and vascular cells in various inflammatory and oxidative conditions."
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"Simvastatin, through enhancing autophagy can promote ASC clearance and thus inhibit the activation of NLRP3 inflammasome."
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"To examine how NLRP3 inflammasome activation is suppressed by statin, the protein expression of NLRP3 inflammasome components, as well as autophagy markers were analyzed by western blot in cells of the collecting duct cell line mpkCCD."
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"In summary, the present study demonstrated that simvastatin inhibited NLRP3 inflammasome in RAECs through inhibiting NADPH oxidase dependent O 2 - production."
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"The inhibitory effects of NADPH oxidase inhibitor, apocynin (APO) on the oligomerization of NLRP3 and ASC induced by high glucose were also observed, suggesting that simvastatin inhibited the NLRP3 inflammasome activation via NADPH oxidase dependent ROS production in RAECs."
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"Our results indicate that simvastatin inhibited the NLRP3 inflammasome pathway and thereby decreased the secretion of HMGB1 from vascular endothelial cells."
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"Simvastatin reduced NLRP3 activation in a diabetic rat model."
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