IndraLab

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OTUB1 activates CCN6. 4 / 4
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"Together, these results show that the protein abundance of CCN6 is enhanced by OTUB1, which possibly inhibits CCN6 protein degradation rather than augmenting its production.3.2 OTUB1 stabilizes CCN6 protein by reducing K48 ubiquitination."
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"To clarify the mechanism by which OTUB1 blocked CCN6 degradation, control and OTUB1 4T1 cells were treated with MG132 or CQ."
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"In the screening experiment, we found that overexpression of OTUB1, a DUB of the ovarian tumour proteases (OTU) subfamily, markedly increased the protein abundance of CCN6 in 4T1 cells (Figure 1B)."
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"In aggregate, these results show that OTUB1 inhibits the aggressive phenotypes, including migration, proliferation and viability, of breast cancer cells by upregulating CCN6 protein abundance.3.6 OTUB1 inhibits breast cancer growth in vivo by upregulating CCN6."
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