IndraLab

Statements

Auranofin inhibits USP14. 14 / 14
| 12 2
reach
"HA-UbVS pretreatment of auranofin could bind the HA tagged UbVS in the purified 26S proteasome, supporting that auranofin inhibits UCHL5 and USP14."
26097878
sparser
"Interestingly, we found that different from bortezomib, AF inhibits 19S proteasome-associated DUBs UCHL5 and USP14 but not the 20S proteasome activity."
25995993
reach
"Interestingly, we found that different from bortezomib, AF inhibits 19S proteasome associated DUBs UCHL5 and USP14 but not the 20S proteasome activity."
25995993
reach
"AF may also elicit cytotoxicity in cancer cells by disrupting protein homeostasis (proteostasis) via proteasomal inhibition, in particular, by targeting the 19 S proteasome-associated deubiquitinases (DUBs), UCHL5, and USP14 [7–9]."
36658130
reach
"Auranofin (Aur) inhibits proteasome associated deubiquitinases (DUBs) UCHL5 and USP14 rather than the 20S proteasome; inhibition of the proteasome associated DUBs is required for Aur induced cytotoxicity; and Aur selectively inhibits tumor growth in vivo and induces cytotoxicity in cancer cells from patients with acute myeloid leukemia [XREF_BIBR]."
25972356
reach
"In detail, Auranofin release from PCN224@Au down-regulated the deubiquitinating enzymes (e.g., CyclinB, USP14 and UCH37) and promoted the proteasomal substrate proteins (e.g., c-Jun and p21) accumulations via activating MAP3Ks, CDK and p53 pathways, which drove ubiquitinated target degradation by proteasome."
40166102
reach
"This was also confirmed by computational molecular docking, K48 linked polyubiquitin disassembly, and HA-UbVS competitive binding assay; these experiments showed that AF might inhibit the proteasomal cysteine DUBs UCHL5 and USP14."
29039082
reach
"It has been documented that Auranofin inhibits the deubiquitinating enzymes, UCHL5/UCH37 and USP14/Ubp6 that belong to cysteine proteases of the UCH and USP families, respectively, thereby affecting the proteasome activity."
40166102
reach
"Similarly, the DUB inhibitor Auranofin can inhibit USP14 and ubiquitin C-terminal hydrolase 5 (UCHL5) as b-AP15 does."
32391376
reach
"Considering previous reports [ 16 ] we further investigated whether auranofin inhibits proteasome DUBs (USP14/UCHL5) of the 19S regulatory particle."
30946948
reach
"The computational model also indicates that an active metabolite of auranofin can inhibit UCHL5 and USP14."
26097878
reach
"The loaded Auranofin in PCN224@Au could be released to down-regulate the deubiquitinating enzymes (e.g., CyclinB, USP14 and UCH37), blockade the deubiquitinating process and promote the accumulations of proteasomal substrate proteins (e.g., c-Jun and p21) to encourage proteasomal degradation of ubiquitinated target proteins."
40166102
sparser
"A previous study has reported that AF indeed inhibits proteasome-associated DUBs, UCHL5 and USP14."
37558718
reach
"Hence, we speculated that Aur inhibited androgen receptor signaling by PKC pathway and promoted the degradation of androgen receptor result from USP14 and UCHL5 inhibition.Interestingly, inhibition of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30639309