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Statements

Astemizole activates KCNH2. 4 / 5
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"Unfortunately, all known hEag1 blockers (including imipramine and astemizole, [6–8] ) also inhibit HERG, which represents a serious difficulty for dissecting the functions of hEag1 and from a practica[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, cisapride (antiemetic) and astemizole (antihistamine) both produce cardiac arrhythmias by inhibiting an off-target, a cardiac ion channel hERG (human Ether-à-go-go -Related Gene) [17] ."
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"Meanwhile, both gene mutation and an hERG inhibitor (astemizole) can inhibit the anti-skeletal muscle dystrophy effect of hERG, suggesting that KCNH2 polymorphisms may be involved in skeletal muscle d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Another crucial point that should be underlined and which favors the hypothesis of SOC inhibition as a primary mechanism for [3 H] NE release inhibition by H 1 receptor antagonists is the existence of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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