IndraLab

Statements


CALM inhibits KCNQ2. 5 / 5
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"Calmodulin activation limits the rate of KCNQ2 K+ channel exit from the endoplasmic reticulum."

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"We show that zinc ionophore, zinc pyrithione (ZnPy), can both prevent or reverse Ca 2+ /CaM-mediated inhibition of Kv7.2."

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"Coexpression of CaM in Chinese hamster ovary (CHO) cells strongly reduced currents of KCNQ2, KCNQ4, and KCNQ5, but not KCNQ1 or KCNQ3."

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"We found that CaM, but not CaM 1234, increased the axonal targeting of KCNQ2 and KCNQ3-I 342A channels compared to mock plasmid."

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"Moreover, overexpression of CaM reduced current amplitudes of KCNQ2, KCNQ4, and KCNQ5, but not those of KCNQ1 and KCNQ3."