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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP22 increases the amount of TGFB1. 4 / 5

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"And overexpression USP22 in A549 induced an increase of TGF-beta1 expression."

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"Ubiquitin specific protease 22 (USP22) reduces the degradation of sirtuin-1 and the expression of FN and TGF-beta1 in AGE treated GMCs, whereas depletion of USP22 promotes sirtuin-1 degradation and the expression of FN and TGF-beta1 in this cell model."

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"Moreover, USP22 may up-regulate TGF-beta1 expression."

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"Ubiquitin specific protease 22 (USP22) reduced Sirt1 ubiquitination and degradation and decreased FN and TGF-beta1 expression in GMCs under both basal and AGEs treated conditions."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

USP22 increases the amount of TGFB1. 4 / 5

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