IndraLab

Statements


USP22 increases the amount of TGFB1. 4 / 5
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"Ubiquitin specific protease 22 (USP22) reduces the degradation of sirtuin-1 and the expression of FN and TGF-beta1 in AGE treated GMCs, whereas depletion of USP22 promotes sirtuin-1 degradation and the expression of FN and TGF-beta1 in this cell model."

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"And overexpression USP22 in A549 induced an increase of TGF-beta1 expression."

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"Moreover, USP22 may up-regulate TGF-beta1 expression."

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"Ubiquitin specific protease 22 (USP22) reduced Sirt1 ubiquitination and degradation and decreased FN and TGF-beta1 expression in GMCs under both basal and AGEs treated conditions."