IndraLab

Statements

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"The metastasis of prostate cancer is also enhanced when EMT is promoted by UCH-L1 (100)."
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"Thus, it maybe possible that EMT induction by UCH-L1 in prostate cancer cells is, at least in part, caused by Akt activation.Unveiling the specific substrates of UCH-L1 is a rate-limiting step to reve[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"UCHL1 induces EMT, and thus enhances the migration and invasion processes in metastatic prostate cell lines [116]."
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"A specific small molecule inhibitor, LDN57444, targeting UCH-L1 significantly inhibited HIF-1 alpha activity in the presence of endogenous UCHL1 expression and suppressed EMT reducing the incidence of distant tumor metastases."
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"Taken together, these data indicate that UCH-L1 promotes EMT in the metastatic DU145 prostate cancer cell line and the enzymatic activity of UCH-L1 is important for the induction of EMT.One of the hal[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We have already shown that UCH-L1, a close relative of UCH-L3, induces EMT and promotes metastasis in prostate cancer cells [11]."
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"UCH-L1 promotes EMT but similarly, the target substrates have not yet been identified."
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"UCH-L1 induced EMT to increase the invasion and metastasis of prostate cancer cells."
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"To investigate whether the induction of EMT by UCH-L1 contributes to the cell migration and invasiveness of prostate cancer cells, we first performed wound healing assays in stable cells."
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"These results indicate that UCH-L3 inhibits EMT by repression of EMT promoting genes such as Snail, Slug, Twist, and MMPs in normal prostate cell lines.In our previous report, we found that UCH-L1 exp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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