IndraLab

Statements

ATXN3 inhibits PRKN. 4 / 5
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"For example, mutant ataxin-3, the causative protein abnormality in SCA3, has been shown to enhance the autophagic degradation of parkin, which may in turn explain some of the parkinsonian features seen in this condition [XREF_BIBR]."
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"63 Interestingly, PolyQ expanded Ataxin-3 promotes degradation of Parkin via autophagy, 64 which helps explain why Parkin protein levels are decreased in the brain of transgenic mice overexpressing polyQ expanded but not wild type Ataxin-3."
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"We reported that the mutant form of ataxin-3, the protein responsible for MJD, promotes the autophagic degradation of parkin."
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"However, the MJF associated form of ataxin-3 promotes Parkin degradation in a proteasome independent manner [XREF_BIBR, XREF_BIBR]."
26517048