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NAMPT binds INSR. 54 / 63
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"Several researchers, including Revollo and Moschen, have not been able to detect PBEF binding to IR."
23787158
sparser
"There were 35 significant ligand-receptor interactions (including source and target) of ORMDL3 + cholangiocytes were predicted, including MIF − (CD74 + CXCR4), MIF − (CD74 + CD44), VEGFA − VEGFR2, and NAMPT-INSR (Fig.  xref a, b)."
34872583
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"Visfatin binds to the insulin receptor at a site distinct from that of insulin and causes hypoglycaemia by reducing glucose release from liver cells and stimulating glucose utilization in adipocytes and myocytes."
18691043
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"Early studies suggested binding of extracellular NAMPT to the insulin receptor as a basis for its activity, however, these studies have since been retracted and no specific extracellular receptor has been identified to date. xref The presence of an NAMPT receptor signaling pathway has also been supported by the induction of IL‐6 by NAMPT in the presence of the inhibitor of NAMPT enzymatic activity FK‐866. xref In contrast, the role of NAMPT enzymatic activity in the pathogenesis of inflammatory arthritis has been supported by studies that demonstrated the role of cellular NAD regulation in lymphocyte development and activation. xref , xref This has been supported further by studies in the collagen‐induced arthritis mouse model that have found inhibition of NAMPT by either FK‐866 or siRNA‐based gene‐silencing inhibits leukocyte activation and infiltration, cytokine production, and overall disease progression. xref , xref Further supporting the role of NAMPT enzyme activity in disease progression, depletion of NAD levels in circulating leukocytes has been associated with the efficacy of FK‐866 in the collagen‐induced arthritis mouse model. xref "
27166432
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"It was also reported that visfatin exerted its insulin-mimetic effects by binding to the IR at a site distinct from insulin [XREF_BIBR]."
26170839
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"Fukuhara et al. suggested that visfatin can bind to the insulin receptor but at a different site."
24695544
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"It has also been demonstrated that recombinant visfatin directly binds to the insulin receptor (IR), leading to tyrosine phosphorylation and resulting in enhanced glucose uptake [14]."
31771561
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"Fukuhara found that PBEF binds to the insulin receptor, which then activates the phosphatidylinositol 3-kinase (PI3K) pathway and causes phosphorylation of AKT and mitogen activated protein kinase (MAPK) (XREF_FIG)."
23787158
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"Unfortunately, Fukuhara 's paper, which reported that PBEF binds to insulin receptors (IR) and activates IR, was later retracted from Science."
23787158
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"Another study reported that visfatin directly binds and activates the insulin receptor to induce the phosphorylation of signal transduction proteins [13]."
31771561
sparser
"Visfatin binds to the insulin receptor at a site distinct from that of insulin and causes hypoglycaemia by reducing glucose release from liver cells and stimulating glucose utilization in adipocytes and myocytes."
18691043
sparser
"Visfatin binds to the insulin receptor at a site distinct from insulin and exerts hypoglycemic effect by reducing glucose release from hepatocytes and stimulating glucose utilization in peripheral tissues."
16733497
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"Visfatin binds to and activates the insulin receptor (IR), thereby exerting insulin-mimetic effects in various cell lines."
17340225
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"Another study reported that visfatin directly binds and activates the insulin receptor to induce the phosphorylation of signal transduction proteins [ xref ]."
31771561
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"XREF_BIBR Visfatin binds to the insulin receptor with similar affinity, but at a site distinct from insulin, with insulin sensitizing effects."
28553078
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"Visfatin binds to the insulin receptor at a site distinct from that of insulin and causes hypoglycaemia by reducing glucose release from liver cells and stimulating glucose utilization in adipocytes and myocytes."
18691043
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"Moreover, visfatin is also tightly bound to a mutant insulin receptor with a reduced affinity to insulin, which suggests that visfatin binds to a different binding site than insulin and is thus noncom[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26451650
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"Several researchers, including Revollo and Moschen, have not been able to detect PBEF binding to IR ( xref , xref )."
23787158
sparser
"The insulin-mimetic actions of visfatin discussed above may be explained by visfatin binding to the insulin receptor, as described in a study by Hug and Lodish (2005) who showed that in addition to [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26451650
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"Visfatin, an adipokine produced mainly by visceral WAT, binds and activates the insulin receptor exerting its insulin-mimetic effect."
22584415
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"Mechanistically, they found that NAMPT bound to insulin receptor but not to the same site as insulin binds."
22140607
sparser
"Visfatin binds to the insulin receptor at a site distinct from insulin and exerts hypoglycemic effect by reducing glucose release from hepatocytes and stimulating glucose utilization in peripheral tissues."
29657573
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"The recombinant visfatin binds with insulin receptor with a dose dependent effect."
25663979
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"Visfatin is mainly produced and secreted by visceral adipocytes and causes insulin-mimetic effects by binding to the insulin receptor."
27246401
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"While it is likely that PBEF does bind to the IR, the picture is unclear as to when and how this happens."
23787158
bel
"It was previously identified as pre-B cell colony-enhancing factor (PBEF), a 52 000 mol. wt cytokine expressed in lymphocytes, and importantly it appears to be an insulin mimetic, both binding to and activating the insulin receptor (Fukuhara et al. 2005)."
16026420
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"Recently, Revollo et al. [19] demonstrated that visfatin did not exert insulin-mimetic effects and there has been no evidence supporting the direct binding of visfatin to the insulin receptor [20] [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20621376
bel
"expression in plasma increases during the development of obesity;exerted insulin mimetic effects in cultured cells; binds to and activates the insulin receptor[visfatin]"
15864338
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"Visfatin binds to insulin receptor and was suggested to have insulin like effects."
27646920
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"Visfatin binds to and activates the insulin receptor (IR), leading to glucose homeostasis [16]."
19100714
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"On the other hand, it is suggested that visfatin can bind and activate insulin receptor (INSR), and downstream signaling pathways xref ."
33888798
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"It has also been demonstrated that recombinant visfatin directly binds to the insulin receptor (IR), leading to tyrosine phosphorylation and resulting in enhanced glucose uptake [ xref ]."
31771561
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"Interestingly, visfatin binds to the insulin receptor with the same affinity as insulin and promotes adipogenesis, an observation consistent with increased visfatin secretion rates from adipocytes following treatment with the PPARgamma agonist rosiglitazone."
23720280
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"Visfatin binds to the insulin receptor and is potentially secreted to compensate for insulin resistance."
27826173
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"Visfatin binds to the insulin receptor at a site distinct from insulin and exerts hypoglycemic effect by reducing glucose release from hepatocytes and stimulating glucose utilization in peripheral tissues."
29657573
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"Visfatin serum levels might correlate with the serum parameters of glucose metabolism and insulin sensitivity if the insulin like activity of visfatin has any physiological importance, and if visfatin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18241953
sparser
"There were 35 significant ligand-receptor interactions (including source and target) of ORMDL3+ cholangiocytes were predicted, including MIF − (CD74 + CXCR4), MIF − (CD74 + CD44), VEGFA − VEGFR2, and NAMPT-INSR (Fig. 7a, b)."
34872583
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"Visfatin binds to the insulin receptor at a site distinct from insulin and exerts hypoglycemic effect by reducing glucose release from hepatocytes and stimulating glucose utilization in the peripheral tissues XREF_BIBR."
24145612
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"PBEF (also called visfatin) can bind to the insulin receptor displaying the insulin-like effect ()."
16188281
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"However, whether visfatin actually mediates its effects by binding to the insulin receptor has been recently debated [XREF_BIBR]."
18400051
sparser
"Although visfatin has insulin mimetic actions, the pro-inflammatory effects of visfatin are unlikely to be mediated via the insulin receptor; given the interaction of visfatin with the insulin recep[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19166999
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"Visfatin binds to the insulin receptor at a site distinct from insulin and exerts hypoglycemic effect by reducing glucose release from hepatocytes and stimulating glucose utilization in peripheral tissues."
16733497
sparser
"The author argues that visfatin binds to insulin receptor and causes hypoglycaemia through the reduction of blood glucose by stimulating its utilization in adipocytes and myocytes as well as reducing its release from liver cells."
28348585
sparser
"Fukuhara ( xref ) found that PBEF binds to the insulin receptor, which then activates the phosphatidylinositol 3-kinase (PI3K) pathway and causes phosphorylation of AKT and mitogen-activated protein kinase (MAPK) ( xref )."
23787158
sparser
"While it is likely that PBEF does bind to the IR, the picture is unclear as to when and how this happens."
23787158
reach
"Surprisingly, visfatin binds to and activates the insulin receptor."
15604363
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"However, it is still interesting whether visfatin binds directly to the insulin receptor at a site distinct from insulin and has hypoglycemic effects by reducing glucose release from hepatocytes and stimulating glucose utilization in peripheral tissue."
22247912
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"Visfatin binds to insulin receptor and exhibits insulin-mimetic actions, therefore, it stimulates glucose uptake in adipocytes and muscle cells and suppresses glucose release from hepatocytes."
25237319
sparser
"Mechanistically, they found that NAMPT bound to insulin receptor but not to the same site as insulin binds."
22140607
reach
"Fukuhara et al. suggested that visfatin can bind to the insulin receptor but at a different site."
24695544
sparser
"The recombinant visfatin binds with insulin receptor with a dose-dependent effect."
25663979
sparser
"Visfatin binds to insulin receptor and exhibits insulin-mimetic actions, therefore, it stimulates glucose uptake in adipocytes and muscle cells and suppresses glucose release from hepatocytes ( xref , xref )."
25237319
reach
"The author argues that visfatin binds to insulin receptor and causes hypoglycaemia through the reduction of blood glucose by stimulating its utilization in adipocytes and myocytes as well as reducing its release from liver cells."
28348585
sparser
"Early studies suggested binding of extracellular NAMPT to the insulin receptor as a basis for its activity, however, these studies have since been retracted and no specific extracellular receptor has been identified to date ( xref )."
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