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NAMPT binds INSR. 132 / 143
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"CD14+ CD16+ monocytes communicated with malignant cells through LGALS9-CD44 and SPP1-CD44, etc. (Figure xref G), while NAMPT-INSR signaling in CD14+ CD16- monocytes was the most prominent in interactions with malignant cells (Figure xref H)."
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"Since e NAMPT can bind to and activate the insulin receptor, its expression level in plasma is positively correlated with obesity 19 ."
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"Visfatin binds and activates the insulin receptor causing a significant drop in glucose release from hepatocytes and stimulating glucose consumption in adipocytes[225]."
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"Visfatin binds to and activates the insulin receptor (IR), leading to glucose homeostasis [16]."
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"Additionally, as shown in xref , the CellChat analysis revealed the presence of ligand receptors, including VEGFB-VEGFR1, NAMPT-INSR, and VEGFA-VEGFR1 ( xref – xref ) which play a crucial role in AS, all participate in communication between these two types of cells, underscoring the importance of their interaction in AS."
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"There were 35 significant ligand-receptor interactions (including source and target) of ORMDL3 + cholangiocytes were predicted, including MIF − (CD74 + CXCR4), MIF − (CD74 + CD44), VEGFA − VEGFR2, and NAMPT-INSR (Fig.  xref a, b)."
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"It was also shown that visfatin binds to the insulin receptor at a different site, and exerts hypoglycemic effect by reducing glucose release from hepatocytes and stimulating glucose utilization in pe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"No visfatin receptor has yet been identified, but it was suggested that visfatin may bind and activate the insulin receptor (for review see Grolla et al. xref )."
37880346
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"It has been demonstrated in recent research that visfatin binds to the insulin receptor in a region distinct from where insulin does [287]."
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"Visfatin binds to the insulin receptor, triggering insulin-mimetic activities."
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"NPCs with high AA metabolic activity demonstrated the ability to engage in cellular communication with NPPCs through ANGPTL4–(ITGA5 + ITGB1), ANGPTL4–CDH11, ANGPTL4–SDC2, FGF2–FGR1, and PDGFC–PDGFRA interactions; with EC through ANGPTL4–(ITGA5 + ITGB1) and ANGPTL4–CDH5 interactions; and with Noto via ANGPTL4–(ITGA5 + ITGB1), ANGPTL4–SDC2, ANGPTL4–SDC3, ANGPTL4–SDC4, FGF2–FGFR1, NAMPT–(ITGA5 + ITGB1), and NAMPT–INSR interactions."
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"However, whether visfatin actually mediates its effects by binding to the insulin receptor has been recently debated [XREF_BIBR]."
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"Another peptide is visfatin, which binds to the IR at a site distinct from that of insulin and causes hypoglycemia by reducing glucose release from liver cells and stimulating glucose utilization in adipocytes and myocytes [170]."
35887136
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"3 , 4 Fukuhara et al. reported that visfatin inhibited decrease plasma glucose concentrations and imitate the effects of insulin by binding to insulin receptor."
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"The recombinant visfatin binds with insulin receptor with a dose-dependent effect."
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"In addition, scRNA-seq and quantitative reverse transcription polymerase chain reaction (qRT-PCR) confirmed that the intercellular communication between secretory phosphoprotein 1 (SPP1)-cluster of differentiation (CD44), insulin-like growth factor (IGF)-1-IGF1r and visfatin-insulin receptor (Insr) associated with bone metabolism and insulin metabolism was increased and enhanced in the liver at 6 w post-infection."
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"In addition, we carried out a kinetic study using isothermal titration calorimetry (ITC) to assess FK-866 affinity and enzyme substrate specificity, and structural modeling for the visfatin and insuli[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16901503
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"While the interaction between NAMPT and INSR (a marker gene of CSCs) was one of the strongest incoming signals ( xref )."
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"Analysis of the structures and biochemical data reveal the enzymatic specificity of visfatin, and suggest the model of visfatin and insulin receptor complex.To solve the structure of Rattus norvegicus[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16901503
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"The author argues that visfatin binds to insulin receptor and causes hypoglycaemia through the reduction of blood glucose by stimulating its utilization in adipocytes and myocytes as well as reducing its release from liver cells."
28348585
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"Visfatin has effects similar to insulin, and can bind to and activate the insulin receptor at a site distinct from insulin."
15780819
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"Visfatin binds to the insulin receptor and is potentially secreted to compensate for insulin resistance."
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"No visfatin receptor has yet been identified, but it was suggested that visfatin may bind and activate the insulin receptor (for review see Grolla et al. )."
37880346
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"Similarly, the activation of NAMPT-INSR signaling between DCs as ligand cells and monocytes expressing high levels of IL-10 as receptor cells highlights another interaction."
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"For communicating with microglia, three unique ligand–receptor pairs of MIF‐ACKR3 , NAMPT‐INSR , and NAMPT‐ ( ITGA5 + ITGB1 ) were detected in endothelial positive cells compared with negative cells."
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"Visfatin binds to and activates the insulin receptor (IR), thereby exerting insulin-mimetic effects in various cell lines."
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"Among them, fibroblasts, endothelial cells, and macrophages targeting GLY high malignant cells work together through certain tumor-promoting signaling pathways, including the NAMPT-(ITGA5 + IAGB1), SPP1-(ITGA5 + ITGB1), NAMPT-INSR, and TGFB1 (ACVR1B + TGFBR2) signaling pairs, which interact to mediate uncontrolled tumor proliferation and growth ( xref B)."
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"While NAMPT-INSR was up regulated in liver, it was down regulated in kidney."
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"It was also reported that visfatin exerted its insulin-mimetic effects by binding to the IR at a site distinct from insulin [XREF_BIBR]."
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"Biochemical studies show that Nampt binds to the insulin receptor tightly, with a dissociation constant of 4.4 nM, at a site that is different from the insulin binding site."
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"Most intriguing of all, it was shown that visfatin binds to the insulin receptor but does not compete with insulin, suggesting that the two proteins bind to different sites [130] ."
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"It was proposed that visfatin mimicked the effects of insulin by binding to the insulin receptor at another site than that of insulin."
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"Visfatin is able to bind and activate the insulin receptor, though at a different site than insulin [61] ."
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"Visfatin binds and activates the insulin receptor causing a significant drop in glucose release from hepatocytes and stimulating glucose consumption in adipocytes[ xref ]."
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"For example, the FGF pathway exerts the most of its effects on cells in SPG1 and SPG2 ( xref ), consistent with a prior observation. xref We also found that myoid cells are the major cell type to receive the signaling activities of the PDGF pathway (including LR pairs PDGFA-PDGFRA, PDGFA-PDGFRB, etc.) and VISFATIN pathway (NAMPT-INSR and NAMPT-ITGA5-ITGB1), while Sertoli cells receive the most of GAS (GAS6-AXL, GAS6-MERTK, and GAS6-TYRO3) signaling activities ( xref )."
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"Specifically, there were issues reproducing the findings that originally demonstrated the binding of visfatin with the insulin receptor [ 5 ]."
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"Fukuhara found that PBEF binds to the insulin receptor, which then activates the phosphatidylinositol 3-kinase (PI3K) pathway and causes phosphorylation of AKT and mitogen activated protein kinase (MAPK) (XREF_FIG)."
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"NAMPT-insulin receptor (INSR)-mediated hepatocyte-HSC crosstalk caused HSCs to develop a myofibroblast phenotype and activated telomere maintenance mechanisms via PARP1 multisite lactylation."
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"Current research has shown that visfatin binds to the insulin receptor at a location different from that of insulin, suggesting that it has properties similar to insulin and stimulates cell growth[ xref ]."
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"By binding to insulin receptor at a site distinct from that of insulin, visfatin exerts insulin-like effects to reduce glucose release and stimulate glucose utilization in adipocytes and myocytes (40)."
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"On day 2, the interactions between Hmgb1 and Tlr2 and Nampt and Insr suggested that growth factors continued to influence the immune response and facilitate repair (Figure S10D)."
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"To further elucidate the impact of MACs on malignant cells, we explored potential ligand‐receptor pairs and found NAMPT‐INSR, LGALS9‐SLC1A5, LGALS9‐CD47, LGALS9‐CD44, GRN‐SORT1, and CD46‐JAG1 are all significantly enriched in cell‐cell communication (Figure  xref ; Figure xref , Supporting Information)."
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"Unfortunately, Fukuhara 's paper, which reported that PBEF binds to insulin receptors (IR) and activates IR, was later retracted from Science."
23787158
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"Several researchers, including Revollo and Moschen, have not been able to detect PBEF binding to IR."
23787158
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"The author argues that visfatin binds to insulin receptor and causes hypoglycaemia through the reduction of blood glucose by stimulating its utilization in adipocytes and myocytes as well as reducing its release from liver cells."
28348585
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"While it is likely that PBEF does bind to the IR, the picture is unclear as to when and how this happens."
23787158
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"Current research has shown that visfatin binds to the insulin receptor at a location different from that of insulin, suggesting that it has properties similar to insulin and stimulates cell growth[102]."
38222785
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"Visfatin binds to the insulin receptor at a site distinct from insulin and exerts hypoglycemic effect by reducing glucose release from hepatocytes and stimulating glucose utilization in peripheral tissues."
16733497
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"It has also been demonstrated that recombinant visfatin directly binds to the insulin receptor (IR), leading to tyrosine phosphorylation and resulting in enhanced glucose uptake [ xref ]."
31771561
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"Fukuhara ( xref ) found that PBEF binds to the insulin receptor, which then activates the phosphatidylinositol 3-kinase (PI3K) pathway and causes phosphorylation of AKT and mitogen-activated protein kinase (MAPK) ( xref )."
23787158
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"Visfatin binds to the insulin receptor with similar affinity, but at a site distinct from insulin [28]."
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"Visfatin binds to and activates the insulin receptor via a distinct binding site from insulin, which stimulates glucose uptake in adipocytes [8] ."
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"Visfatin binds to the insulin receptor at a site distinct from insulin and exerts hypoglycemic effect by reducing glucose release from hepatocytes and stimulating glucose utilization in the peripheral tissues XREF_BIBR."
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"We found that NAMPT-INSR and TGFB1-(TGFBR1+TGFBR2 ) were only present in the TR but not in the TC."
39755578
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"It has been described that visfatin binds to the insulin receptor and lower plasma glucose levels in cultured cells; however, its exact role as insulin mimicking cytokine is still under investigation."
36077676
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"Visfatin binds to the insulin receptor at a site distinct from insulin and exerts hypoglycemic effect by reducing glucose release from hepatocytes and stimulating glucose utilization in peripheral tissues."
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"Another study reported that visfatin directly binds and activates the insulin receptor to induce the phosphorylation of signal transduction proteins [ xref ]."
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"Early studies suggested binding of extracellular NAMPT to the insulin receptor as a basis for its activity, however, these studies have since been retracted and no specific extracellular receptor has been identified to date. xref The presence of an NAMPT receptor signaling pathway has also been supported by the induction of IL‐6 by NAMPT in the presence of the inhibitor of NAMPT enzymatic activity FK‐866. xref In contrast, the role of NAMPT enzymatic activity in the pathogenesis of inflammatory arthritis has been supported by studies that demonstrated the role of cellular NAD regulation in lymphocyte development and activation. xref , xref This has been supported further by studies in the collagen‐induced arthritis mouse model that have found inhibition of NAMPT by either FK‐866 or siRNA‐based gene‐silencing inhibits leukocyte activation and infiltration, cytokine production, and overall disease progression. xref , xref Further supporting the role of NAMPT enzyme activity in disease progression, depletion of NAD levels in circulating leukocytes has been associated with the efficacy of FK‐866 in the collagen‐induced arthritis mouse model. xref "
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"In addition, we carried out a kinetic study using isothermal titration calorimetry (ITC) to assess FK-866 affinity and enzyme substrate specificity, and structural modeling for the visfatin and insuli[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16901503
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"Most intriguing of all, it was shown that visfatin binds to the insulin receptor but does not compete with insulin, suggesting that the two proteins bind to different sites [130] ."
18054218
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"It has been shown that visfatin can bind to the insulin receptor [114,120] or TLR4 [121]."
38275812
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"Since e NAMPT can bind to and activate the insulin receptor, its expression level in plasma is positively correlated with obesity 19 ."
38244254
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"Analysis of the structures and biochemical data reveal the enzymatic specificity of visfatin, and suggest the model of visfatin and insulin receptor complex."
16901503
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"Several researchers, including Revollo and Moschen, have not been able to detect PBEF binding to IR ( xref , xref )."
23787158
sparser
"Another peptide is visfatin, which binds to the IR at a site distinct from that of insulin and causes hypoglycemia by reducing glucose release from liver cells and stimulating glucose utilization in adipocytes and myocytes [ xref ]."
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"Moreover, recent studies have shown that visfatin could bind and activate the Toll-like receptor 4 (95) and also due to its insulin-mimetic activity, can bind the insulin receptor and cause insulin resistance and consequently regulate glucose levels (96)."
34559064
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"While it is likely that PBEF does bind to the IR, the picture is unclear as to when and how this happens."
23787158
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"Mechanistically, they found that NAMPT bound to insulin receptor but not to the same site as insulin binds."
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"Visfatin serum levels might correlate with the serum parameters of glucose metabolism and insulin sensitivity if the insulin like activity of visfatin has any physiological importance, and if visfatin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18241953
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"Among these, Nicotinamide phosphoribosyl transferase (NAMPT)-related pathways, such as NAMPT-INSR and NAMPT-(ITGA5 + ITGB1), exhibited the highest communication probability (Fig.  xref D)."
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"The ligand-receptor pairs of NAMPT-INSR and NAMPT- (ITGA5 + ITBG1) were of particular interest, with monocytes identified as the primary cell source of NAMPT (Fig.  xref H)."
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"Visfatin is mainly produced and secreted by visceral adipocytes and causes insulin-mimetic effects by binding to the insulin receptor."
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"Visfatin binds to insulin receptor and was suggested to have insulin like effects."
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"The insulin-mimetic actions of visfatin discussed above may be explained by visfatin binding to the insulin receptor, as described in a study by Hug and Lodish (2005) who showed that in addition to [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, visfatin is also tightly bound to a mutant insulin receptor with a reduced affinity to insulin, which suggests that visfatin binds to a different binding site than insulin and is thus noncom[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Visfatin binds to insulin receptor and exhibits insulin-mimetic actions, therefore, it stimulates glucose uptake in adipocytes and muscle cells and suppresses glucose release from hepatocytes."
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"Recently, Revollo et al. [19] demonstrated that visfatin did not exert insulin-mimetic effects and there has been no evidence supporting the direct binding of visfatin to the insulin receptor [20] [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Visfatin binds to the insulin receptor with similar affinity but at a site distinct from insulin [32]."
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"Ligand–receptor pairs, such as PROS1-AXL , NAMPT-INSR , MDK-LRP1 , MDK-ALK , GAS6-MERTK , and GAS6-AXL , between endothelial and tumor cells exhibited a higher communication possibility than that between endothelial cells and thyrocytes (Fig.  xref B)."
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"Visfatin binds to the insulin receptor, triggering insulin-mimetic activities."
36457996
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"Meng Zhou et al xref discovered that various signaling pathways, such as those involving VISTANT, SPP1, and IGF, as well as receptor-ligand pairs, including NRG1-ERBB4, SPP1-CD44, Igf1-Igf1r, and NAMPT-INSR, may play significant roles in DKD by inducing crosstalk between renal and immune cells."
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"Among the identified L-R interactions in the heart chambers, NAMPT-INSR is the only L-R pair where the heart adipocytes act both as senders and receivers."
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"Additionally, NAMPT-INSR signaling was identified as significantly prevalent in communications within non-T cell populations (Fig.  xref F)."
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"The recombinant visfatin binds with insulin receptor with a dose dependent effect."
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"Surprisingly, visfatin binds to and activates the insulin receptor."
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"Since it was previously reported that visfatin binds to and activates insulin receptor [1] , we examined the possible involvement of insulin receptor for the visfatin-induced relaxation."
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"Interestingly, visfatin binds to the insulin receptor with the same affinity as insulin and promotes adipogenesis, an observation consistent with increased visfatin secretion rates from adipocytes following treatment with the PPARgamma agonist rosiglitazone."
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"It was also shown that visfatin binds to the insulin receptor at a different site, and exerts hypoglycemic effect by reducing glucose release from hepatocytes and stimulating glucose utilization in pe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18778865
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"However, it is still interesting whether visfatin binds directly to the insulin receptor at a site distinct from insulin and has hypoglycemic effects by reducing glucose release from hepatocytes and stimulating glucose utilization in peripheral tissue."
22247912
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"Visfatin binds to the insulin receptor at a site distinct from insulin and exerts hypoglycemic effect by reducing glucose release from hepatocytes and stimulating glucose utilization in peripheral tissues."
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"Pathway based CellChat analysis showed NAMPT-INSR (VISFATIN pathway) was a common L-R pair among all immune cell types to OBC-2."
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"On the other hand, it is suggested that visfatin can bind and activate insulin receptor (INSR), and downstream signaling pathways xref ."
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"In addition, visfatin, also known as pre-B cell colony-enhancing factor, mimics the effects of insulin and binds to the insulin receptor at a site different to that of insulin [3] ."
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"The interactions through different immune cell types to the late-stage OBC regarding NAMPT-INSR suggested a complex regulatory mechanism may involve in this functional L-R pair."
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"Visfatin activates its target cells by binding to the insulin receptor (IR) and exerts multiple insulin-mimetic effects, including enhanced glucose uptake and increased triglyceride synthesis (10, 32–34)."
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"It has been described that visfatin binds to the insulin receptor and lower plasma glucose levels in cultured cells; however, its exact role as insulin mimicking cytokine is still under investigation."
36077676
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"It has been demonstrated in recent research that visfatin binds to the insulin receptor in a region distinct from where insulin does [ xref ]."
40141412
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"SPP1-CD44, NRG1-ERBB4, NAMPT-INSR, and Igf1-Igf1r receptor ligand pairs were enhanced in DKD, which mediated the communication between immune-inflammatory cells and innate cells."
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"VISTANT, SPP1, and IGF signaling pathways and SPP1-CD44, NRG1-ERBB4, NAMPT-INSR, and Igf1- Igf1r receptor ligand pairs might occupy essential place in the occurrence and progress of DKD."
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"Mechanistically, they found that NAMPT bound to insulin receptor but not to the same site as insulin binds."
22140607
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"The expression of another receptor ligand pairs NAMPT-INSR was also tested."
37497063
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"PLG-PARD3, SPP1-CD44, SPP1-(ITGA9+ITGB1), NRG1-ERBB4, and NAMPT-INSR were identified as essential bridges between T cells, monocytes, and PCTs in human datasets."
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"It has also been demonstrated that recombinant visfatin directly binds to the insulin receptor (IR), leading to tyrosine phosphorylation and resulting in enhanced glucose uptake [14]."
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"Another study reported that visfatin directly binds and activates the insulin receptor to induce the phosphorylation of signal transduction proteins [13]."
31771561
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"In conclusion, our current study analyzed immune cells and inflammation-related pathways in DKD, further revealing that VISTANT, SPP1, GALECTIN and IGF signaling pathways and SPP1-CD44, NRG1-ERBB4, NAMPT-INSR, Sema3g (Nrp1+Plxna4), Igf1- Igf1r receptor ligand pairs might occupy an important place in the occurrence and progress of DKD."
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"Furthermore, ligand–receptor pair analysis showed that high-CFRG-score T_cells preferentially sent signals to other cells by TNF−TNFRSF1B, TNF−TNFRSF1A, TIGIT−NECTIN2, SELPLG−SELL, NAMPT–INSR, and NAMPT−(ITGA5 + ITGB1) ( xref H)."
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"PBEF (also called visfatin) can bind to the insulin receptor displaying the insulin-like effect ()."
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"This is further evidenced by the bubble plots, which identified the NAMPT-INSR interaction as a critical ligand-receptor pair in healthy lung, COPD, IPF, and COVID-19, together with SEMA4D-PLXNB2 and ADGRE5-CD55."
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"Although earlier studies demonstrated that visfatin binds to and activates insulin receptor [1] , we could not find any inhibition of visfatin-induced relaxation by a specific insulin receptor inhibit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our study further demonstrated the intercellular communication between pulmonary epithelial and lymphocyte subsets through the crucial ligand-receptors in pulmonary diseases, e.g., NAMPT-INSR, SEMA4D-PLXNB2, ADGRE5-CD55 and CD99-CD99 and signaling pathway (APP and CD74)."
39920481
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"Ligand–receptor analysis identified specific ligand–receptor pairs, including NAMPT–INSR, IGF1–IGF1R, PTN–NCL and DLK1–NOTCH2 among others (Fig. xref )."
40033047
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"Visfatin binds the insulin receptor (IR), inducing glucose uptake into adipose tissue and skeletal muscle in both mice and humans."
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"Nevertheless, most studies indicate that visfatin can control cellular processes by binding to the insulin receptor (INSR) [10]."
39292698
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"Visfatin binds to the insulin receptor at a site distinct from that of insulin and causes hypoglycaemia by reducing glucose release from liver cells and stimulating glucose utilization in adipocytes and myocytes."
18691043
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"Fukuhara et al. suggested that visfatin can bind to the insulin receptor but at a different site."
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"Because visfatin exerts insulin-mimetic effect by binding to the insulin receptor [3] , we examined whether ERK1/2 and Akt, proteins involved in insulin signaling pathway, were phosphorylated in bMEC [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the near future, further studies may reveal a physiological activator of visfatin via increase of intracellular cAMP concentration in mammary epithelial cells.In various cell types, visfatin exerts[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Visfatin in myocytes binds and activates the insulin receptor, which causes an effect that only mimics the action of insulin, as confirmed by studies showing the lack of involvement of insulin signalling pathways in the activity of visfatin [ xref ]."
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"Visfatin in myocytes binds and activates the insulin receptor, which causes an effect that only mimics the action of insulin, as confirmed by studies showing the lack of involvement of insulin signalling pathways in the activity of visfatin [43]."
38139115
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"Visfatin binds to the insulin receptor at a site distinct from insulin and exerts hypoglycemic effect by reducing glucose release from hepatocytes and stimulating glucose utilization in peripheral tissues."
29657573
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"Although visfatin has insulin mimetic actions, the pro-inflammatory effects of visfatin are unlikely to be mediated via the insulin receptor; given the interaction of visfatin with the insulin recep[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The most surprising findings were that visfatin binds directly to the insulin receptor, activates downstream signaling cascades, and thereby mimics insulin action in vitro and in vivo ( Fukuhara et al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17983577
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"Visfatin binds to the insulin receptor at a site distinct from that of insulin and causes hypoglycaemia by reducing glucose release from liver cells and stimulating glucose utilization in adipocytes and myocytes."
18691043
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"These results suggested that a complex and dynamic intercellular communication network during HIRI, especially the VISFATIN and MIF signaling pathways (MIF-ACKR3, MIF-(CD74 + CXCR4), NAMPT-(ITGA5 + ITGB1), and NAMPT-INSR), was upregulated in the HIRI group."
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"Further analysis revealed that intercellular communication via MIF-ACKR3, MIF-(CD74 + CXCR4), NAMPT-(ITGA5 + ITGB1), and NAMPT-INSR ligand-receptor pairs in macrophages may have a significant effect on HIRI."
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"The upregulation of NAMPT-(ITGA5 + ITGB1) and NAMPT-INSR between macrophages and endothelial cells was also observed in a chronic hepatitis B (CHB) mouse model."
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"Moreover, the M1-, M2-, and LAM-type macrophages interacted with the Mhb-type macrophages through the ligand receptor NAMPT-INSR with significantly increased intensity in the plaques of the symptomatic patients."
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"Fukuhara et al. suggested that visfatin can bind to the insulin receptor but at a different site."
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"XREF_BIBR Visfatin binds to the insulin receptor with similar affinity, but at a site distinct from insulin, with insulin sensitizing effects."
28553078
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"Visfatin binds to the insulin receptor at a site distinct from that of insulin and causes hypoglycaemia by reducing glucose release from liver cells and stimulating glucose utilization in adipocytes and myocytes."
18691043
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"Visfatin, an adipokine produced mainly by visceral WAT, binds and activates the insulin receptor exerting its insulin-mimetic effect."
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"Visfatin binds to insulin receptor and exhibits insulin-mimetic actions, therefore, it stimulates glucose uptake in adipocytes and muscle cells and suppresses glucose release from hepatocytes ( xref , xref )."
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