IndraLab

Statements

NR3C2 binds IL10. 8 / 8
| 1 7
sparser
"MCR was significantly associated with IL-10, IL-10 to TNF-α ratio, sarcopenia, body fat indices and systemic inflammation."
37371414
sparser
"The association of IL10 SNPs, rs1800896 (HR = 1.673; 95%CI= 1.200–2.331; p value=0.002) and rs3024498 (HR =1.896; 95%CI= 1.290–2.786; p value=0.001) with incident MCR in the full model was significant even when adjusted for OPUS/OPEL status to account for the LonGenity study design."
28705468
sparser
"IL10 gene variants rs1800896 and rs3024498, which were associated with incident MCR, have not, to our knowledge, been reported to predict incident MCI."
28705468
sparser
"In Model 3, after adjustment for body fat percentage, MCR was significantly associated with reduced IL-10 to TNF-α ratio (aOR 0.98, 95% CI 0.97–0.99) and reduced IL-10 (aOR 0.22; 95% CI 0.05–0.98)."
37371414
sparser
"MCR was also significantly associated with low IL-10 and IL-10 to TNF-α ratio after adjusting for sarcopenia and body fat percentage."
37371414
reach
"The authors state that this study is one of the first to demonstrate an association between IL-10 and MCR in pre-frail older adults and could serve as a future therapeutic target.Motor signs and cognitive performance appear to be parallel manifestations of underlying brain disease."
38672005
sparser
"Our study is one of the first to show an association of IL-10 with MCR in pre-frail older adults, which requires further validation at the population level and could serve as a future therapeutic target."
37371414
sparser
"The association of the IL10 polymorphisms rs1800896 (HR= 1.758; 95%CI= 1.208–2.560; p value=0.003) and rs3024498 (HR= 1.984; 95%CI= 1.305–3.017; p value=0.001) with incident MCR still remains significant even after removing these 15 MCI cases."
28705468