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USP18 activates ISG. 2 / 2

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"USP18 specifically removes the ISGylation from substrate proteins by interferon-stimulated (ISG) gene 15 and also regulates the interferon signaling pathway to block ISGs (88,89)."

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"In cell culture, siRNA mediated depletion of USP18 enhanced ISG induction as well as the antiviral effect of IFN-alpha against HCV replication."

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IndraLab

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USP18 activates ISG. 2 / 2

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