IndraLab

Statements

ATM phosphorylates USP37. 9 / 9
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"Mechanistically, DNA double-strand breaks (DSB) promotes ATM phosphorylation of USP37 and enhances the binding between USP37 and BLM."
34606619
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"Mechanistically, USP37 is phosphorylated by ATM following DNA damage, which increases the binding between USP37 and BLM and leads to BLM deubiquitylation."
34606619
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"These results confirm that ATM phosphorylates USP37 following DNA damage."
34606619
sparser
"Mechanistically, Chenming Wu et al. discovered that DNA double-strand breaks promote the phosphorylation of USP37 by ATM and enhance the binding between USP37 and the RecQ helicase BLM ( xref )."
38516408
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"Interestingly, WT USP37 was phosphorylated by ATM, which in turn increased its deubiquitination activity towards BLM, while the S114A mutant did not have this effect."
34606619
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"Together, these data suggest that USP37 phosphorylation by ATM is important for its regulation of DDR."
34606619
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"Mechanistically, DNA damage activates ATM which phosphorylates USP37 and activates its deubiquitinase activity to stabilize BLM."
34606619
sparser
"Following DNA damage, the DUB USP37 is phosphorylated by ATM."
38137461
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"Mechanistically, Chenming Wu et al. discovered that DNA double-strand breaks promote the phosphorylation of USP37 by ATM and enhance the binding between USP37 and the RecQ helicase BLM (111)."
38516408