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Ezogabine increases the amount of KCNQ3. 2 / 2

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"Retigabine activates KCNQ2 and KCNQ3 expressed in Chinese Hamster Ovary (CHO) cells with an EC 50 value of 1.7 (Rundfeldt and Netzer, 2000) and 0.34 muM when KCNQ2 and KCNQ3 were expressed in Xenopus [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Treatment with retigabine decreased the level of the SUMO E1 SAE1 and decreased the SUMOylation levels of Kv7.2 and Kv7.3, which contributed to the opening of Kv7.2 and Kv7.3."

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Ezogabine increases the amount of KCNQ3. 2 / 2

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