IndraLab

Statements

PA activates KCNMA1. 4 / 4
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"This model was used to assess the PA induced BK channel antagonistic effects with a broad dose range (1-50 muM) and known documented activity [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Therefore, AST is proposed to provide protection and was able to reverse PA induced BK channel blocking toxicity in the C. elegans model."
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"The PA induced BK channel antagonistic effect may correlate with and justify the abnormality in Asp, Glu, GABA, DA, 5-HT, and NE levels in the PA treated group."
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"The counteracting effect of AST and DHA for PA induced BK channel antagonistic activity in the C. elegans model might have restored the normal levels of targeted neurotransmitters."
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