IndraLab

Statements


IL1B increases the amount of CYLD. 3 / 3
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"Such a function of CYLD was suggested by the finding that the expression of CYLD is induced by proinflammatory cytokines, TNF-alpha and IL-1beta, and the Gram negative bacterium Haemophilus influenzae."

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"As shown in Fig. 1 , the protein level of endogenous CYLD was highest in THP-1 cells among these vascular cells and was upregulated by IL-1β and TNFα in HAECs and THP-1 cells but not in HASMCs."

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"One possibility is that Cyld expression is upregulated by TNF and IL-1beta, via IKK-NF-kappaB pathway XREF_BIBR, XREF_BIBR, XREF_BIBR triggers its association with Itch."