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USP13 activates WWP1. 3 / 3
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"At the same time, the detection of various ubiquitination-related proteins, including PTEN ubiquitination inhibitory proteins USP7 [36] and USP13 [37] and PTEN ubiquitination-promoting protein NEDD4-1 [38], WWP1 [34], WWP2 [39] and FBXO22 [35], showed that only WWP1 and FBXO22 were significantly down-regulated, while others were not significantly changed (Fig. 4e)."
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"In contrast, WWP1 was elevated in the USP13 group, and I3C suppressed the upregulation of WWP1 mediated by USP13 overexpression (Fig. 6L)."
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"Our results indicated that MG132 could restrain the degradation of WWP1 induced by USP13 knockdown, whereas HCQ could not (Fig. 4E)."
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