IndraLab

Statements

USP5 decreases the amount of FAS. 3 / 3
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"USP5 inhibits the intrinsic apoptosis pathway by regulating the expression of the p53-dependent Fas cell surface death receptor (FAS) [ 40 ]."
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"Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway."
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"We used Usp5 knockdown (KD), overexpression and enzyme inhibition to demonstrate that Usp5 suppresses p53 and FAS levels in melanoma and is associated with loss of checkpoint control and apoptotic sensitivity to kinase inhibitors and other agents."
24980819