IndraLab

Statements


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"USP8 interacts with AIP4 and retains this E3 ubiquitin ligase in a state in which it can interact with FLIP S."

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"Collectively, our findings demonstrate a functional cooperation between USP8, AIP4, and the ESCRT-0 machinery at the early sorting phase of CXCR4 and underscore the versatility of USP8 in shaping trafficking events at the early-to-late endosome transition."

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"A direct interaction between USP8 and AIP4 has not been reported, and it is possible that instead of directly deubiquitinating AIP4, USP8 may alter the ability of other E3 ligases (or perhaps of AIP4 itself) to stimulate AIP4 K63 polyubiquitination."