IndraLab

Statements

CD44 binds ADAM10. 13 / 14
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"Together, these data show that ADAM10 interacts with CD44 and PrPc, and initiates CD44 and PrPc intramembrane proteolysis followed by nuclear transport and signaling of the cytoplasmic domain."
33413403
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"To further validate these findings, we examined the potential of a physical interaction between CD44 and ADAM10 using co-immunoprecipitation."
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"Pre-incubation with simvastatin prior to treatment with IL-1β + Oncostatin M decreased the level of CD44 fragmentation, decreased the proportion of CD44 that transits into the lipid raft fractions, decreased ADAM10 activity and diminished the interaction between CD44 and ADAM10."
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"In TNBC cells, we find that ADAM10 interacts with CD44 and PrPc and initiates their intramembrane proteolysis followed by nuclear transport and signaling of the cytoplasmic domain."
33413403
sparser
"To further validate these findings, we examined the potential of a physical interaction between CD44 and ADAM10 using co-immunoprecipitation."
27242325
reach
"Second, simvastatin inhibits the interaction between CD44 and ADAM10 due to a decrease in the proportion of CD44 existing in lipid raft.CD44 cleavage occurs in a variety of tissues and is mediated by [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We demonstrated by co-immunoprecipitation analysis that the ADAM10 associated with CD44 in control, untreated chondrocytes was predominately the 90 kD immature isoform whereas following IL-1β + OSM tr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, we showed that simvastatin inhibited the generation of the mature form of ADAM10, ADAM10 activity as well as the interaction of CD44 and ADAM10.We demonstrated by co-immunoprecipitation a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Second, simvastatin inhibits the interaction between CD44 and ADAM10 due to a decrease in the proportion of CD44 existing in lipid raft."
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sparser
"In addition, simvastatin-mediated inhibition of cholesterol biosynthesis and the dissolution of lipid rafts is likely responsible for preventing interactions between CD44 and ADAM10, thereby blocking [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"ADAM10 interacts with CD44 and PrPc and promotes their nuclear transportation."
33413403
reach
"In addition, simvastatin mediated inhibition of cholesterol biosynthesis and the dissolution of lipid rafts is likely responsible for preventing interactions between CD44 and ADAM10, thereby blocking [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27242325
reach
"Pre-incubation with simvastatin prior to treatment with IL-1beta+ Oncostatin M decreased the level of CD44 fragmentation, decreased the proportion of CD44 that transits into the lipid raft fractions, decreased ADAM10 activity and diminished the interaction between CD44 and ADAM10."
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