IndraLab

"IL-1B and IL-1A are encoded by distinct genes and bind both to IL-1R1, found on nearly every cell and IL-1R2 ( xref )."

"IL1R2 (2q11): Interleukin 1 receptor, type II binds IL1a, IL1b and IL1R1, inhibiting the activity of these ligands."

"Between T-cells and neutrophils specific interactions involved CCR1 / CCL3 or CCL3L1 (pro-inflammation), CD2 / CD58 (co-stimulatory/immunogenic pathway) and CD94:NKG2E / HLA-F (anti-viral immune-surveillance), whereas between epithelial cells and neutrophils, IL1R / IL1A or IL1B or IL1R interactions were most pronounced (which can facilitate productive neutrophil immunity in an immune-controlled/immunogenic context). xref , xref , xref Numerous interactions were also observed between epithelial cells and monocyte/macrophages: GAS6 or PROS1 / AXL (receptor-mediated phagocytosis), ADORA2B / ENTPD1 (extracellular ATP degradation/suppression), CD83 / PECAM1 (immune activation) and semaphorins interacting with their plexin and NRP receptors (tissue re-modelling and repair)."

"Because mice deficient in the IL-1R cannot respond to IL-1, this result demonstrated that either IL-1a or IL-1b, both of which bind to the IL-1R, contributed to acute pathology after rVSV immunization."

"The binding of IL-1alpha or IL-1beta to IL1R is an early step in IL-1 signal transduction and blocking this interaction may therefore be a useful target for the development of new drugs."

"Interleukin-1α (IL1α) and interleukin-1β (IL1β) both bind to IL-1R1 to initiate cell signaling."