IndraLab

Statements

HULC increases the amount of USP22. 3 / 3
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"In turn, HULC strongly increased USP22 protein levels and promoted SIRT1 deubiquitylation, consequently decreasing the UPP-mediated degradation of SIRT1 and increased its protein stability."
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"HULC can increase the expression of USP22 (Ubiquitin Specific Peptidase 22) via inhibiting miR-6886−3p, miR-6825−5p, and miR-6845−5p."
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"The overexpression of HULC in HCC cells increased the expression level of USP22, leading to a reduction in the ubiquitin-mediated degradation of COX-2 proteins, resulting in the upregulation of COX-2 expression and half-life prolongation."
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