IndraLab

Statements

CYLD inhibits AP1. 6 / 6
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"CYLD loss-of-function promotes human SCC in an AP1 dependent manner."
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"We therefore examined whether the loss of CYLD also promoted the activation of AP-1."
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"In contrast, expression of the wild type CYLD inhibited SCC tumorigenesis and AP1 function."
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"Taken together, these findings indicated that CYLD negatively regulates the activation of TAK1, p38, and AP-1."
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"We found that CYLD m increased AP1 driven expression both in the presence and absence of EGF; whereas CYLD WT reduced AP1 activity in both conditions (XREF_FIG)."
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"CYLD blocks ERK-, p38-/AP-1, and c-Myc pathways and inhibits the antioxidant capacity of Nrf2, thereby enhancing oxidative stress in the heart (Figure 4)."
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