IndraLab

Statements

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"Recent studies have demonstrated that USP1 inhibition induced apoptosis and suppressed cell proliferation in acute myeloid leukemia ( AML ) and MM cells 12 , 13 ."
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"Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells."
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"Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC."
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"Similarly, pharmacological inhibition of USP1 by SJB3-019A significantly repressed cell proliferation and triggered B-ALL cell apoptosis."
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"Notably , downregulation of USP1 could inhibit cell proliferation and promote apoptosis in a variety of solid tumors 9,11,12 ."
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"ML323 , a USP1 inhibitor triggers cell cycle arrest , apoptosis and autophagy in esophageal squamous cell carcinoma cells ."
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"USP1 downregulation decreased expressions of fibrosis-related genes , suppressed proliferation , and promoted apoptosis in TGF-beta1-induced LX-2 cells , which were reversed by SNAIL overexpression ."
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"Inhibition of USP1 induces apoptosis via ID1 / AKT pathway in B-cell acute lymphoblastic leukemia cells Deubiquitylating enzyme ubiquitin-specific protease 1 ( USP1 ) has been reported to be aberrantly overexpressed in cancers , and it plays a critical role in regulating various cellular processes , such as cell proliferation , apoptosis , and cell differentiation ."
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"Inhibition of USP1 induces apoptosis via ID1 and AKT pathway in B-cell acute lymphoblastic leukemia cells."
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"A recent study demonstrated that USP1 inhibition induces apoptosis in leukemic cells 30."
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