IndraLab

Statements

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"Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells."
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"USP1 downregulation decreased expressions of fibrosis-related genes , suppressed proliferation , and promoted apoptosis in TGF-beta1-induced LX-2 cells , which were reversed by SNAIL overexpression ."
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"Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC."
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"A recent study demonstrated that USP1 inhibition induces apoptosis in leukemic cells 30."
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"Recent studies have demonstrated that USP1 inhibition induced apoptosis and suppressed cell proliferation in acute myeloid leukemia ( AML ) and MM cells 12 , 13 ."
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"Inhibition of USP1 induces apoptosis via ID1 and AKT pathway in B-cell acute lymphoblastic leukemia cells."
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"They also reported that USP1 stabilizes survivin (BIRC5) and suppresses apoptosis in Ewing sarcoma [22]."
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"65 The mechanisms by which USPs are associated with PCD in tumor cell development were also elucidated, e.g., inhibition of USP1 induces apoptosis and autophagy in hepatocellular carcinoma66; depletion of USP35 increases sensitivity to cisplatin-induced apoptosis in NSCLC67; and USP35 can stabilize the RRS in NSCLC cells by RRBP1 to mitigate endoplasmic reticulum (ER) stress-induced apoptosis.68 Next, we will briefly describe the structure and function of USPs and describe the possible mechanisms of USPs in the PCD of different BC cells (Fig. 3)."
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"Moreover, USP1 knockout induced G0/G1 cell cycle arrest, apoptosis, and autophagy."
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"Similarly, pharmacological inhibition of USP1 by SJB3-019A significantly repressed cell proliferation and triggered B-ALL cell apoptosis."
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"Moreover, the knockdown of USP1 can induce B-cell ALL apoptosis through inhibiting ID1/AKT signaling pathway [222] ."
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"ML323 , a USP1 inhibitor triggers cell cycle arrest , apoptosis and autophagy in esophageal squamous cell carcinoma cells ."
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"In addition, USP1 knockout induced apoptosis (Fig. 7D, E and Supplementary Fig. 7D, E), cell cycle arrest (Fig. 7B, C and Supplementary Fig. 7B, C), and autophagy (Fig. 7F and Supplementary Fig. 7F)."
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"It was found that compared to cells transfected with S2739 alone, the USP1 OE group significantly promoted tumor cell proliferation, migration and invasion, but inhibited tumor cell apoptosis."
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"In DLBCL, inhibition of USP1 expression by shRNA induced apoptosis and autophagy, which caused the reversion of chemotherapy [16]."
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"In addition, USP1 depletion promoted apoptosis in HLF cells, while further TAZ overexpression partially reduced the percentage of apoptotic cells (Fig. 4G, H)."
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"miR-375 overexpression down-regulated USP1 expression and negatively regulated USP1-mediated NPC cell migration, invasion, and apoptosis."
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"Inhibition of USP1 induces apoptosis via ID1 / AKT pathway in B-cell acute lymphoblastic leukemia cells Deubiquitylating enzyme ubiquitin-specific protease 1 ( USP1 ) has been reported to be aberrantly overexpressed in cancers , and it plays a critical role in regulating various cellular processes , such as cell proliferation , apoptosis , and cell differentiation ."
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"Notably , downregulation of USP1 could inhibit cell proliferation and promote apoptosis in a variety of solid tumors 9,11,12 ."
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"Ectopic expression of USP1 statistically enhanced cell proliferation, migration and invasion abilities and decreased cell apoptosis and chemo-sensitivity in 143B and U2OS cells."
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