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USP35 decreases the amount of Reactive Oxygen Species. 4 / 4
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"In addition, BRD4 overexpression dramatically decreased Lipid ROS level induced by USP35 knockdown in two cell lines (Fig. 6B, Supplementary Fig. 1F)."
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"Furthermore, silencing USP35 increased Lipid ROS levels in ER+ breast cancer cells, which were also attenuated by Ferro-1 treatment (Fig. 1D, Supplementary Fig. 1A)."
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"We found that SLC7A11 overexpression partially reduced the increase in Lipid ROS level induced by USP35 knockdown (Fig. 3D, Supplementary Fig. 1D)."
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"Meanwhile, knockdown of USP35 dramatically enhanced Lipid ROS level induced by Erastin or RSL3 treatment in MCF-7 and ZR-75-1 cells (Fig. 2B, Supplementary Fig. 1B)."
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