IndraLab

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FN1 activates ITGB1. 12 / 19
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"In short, PLA2R1 knockdown promotes the tumorigenesis and proliferation of thyroid cancer via the FN1-mediated ITGB1/FAK axis in vivo."
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"The objective of our study was to determine how FN1 may enhance CTC migration by regulating ITGB1 and SLUG."
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"In our previous research, we found that FN could increase cell adhesion 1 , so we investigated whether or not activation of integrin beta1 by FN could improve survival and increase gefitinib resistance."
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"Integrin-beta1 activation by fibronectin fragments leads to the binding of this receptor to its binding partners."
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"These data suggested that activation of integrin beta1 by FN could induce gefitinib resistance."
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"To further confirm that the activation of integrin beta1 by FN have some effect on EGFR TKI resistance, we detected the apoptosis of PC9, PC9/D6 cells treated with gefitinib with or without FN."
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"After activation of integrin beta1 by FN, phosphorylation of c-MET, FAK, AKT, and ERK were all increased significantly."
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"It can be assumed that targeted regulation of PLA2R1 expression inhibits thyroid cancer progression through the FN1-mediated ITGB1/FAK axis.However, it must be mentioned that our study is limited by the small sample size and single center data."
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"By this logic, we established quantitative screening models to develop novel CD29 functional regulators, using specific agonistic antibodies to CD29, other CD29-associated adhesion molecules, such as [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, fibronectin is known to activate integrin-beta1 and cell-matrix adhesion [17]."
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"In SMCs, fibronectin coated substrates promoted localization of integrin beta 1 into FAs; however, in podocytes, integrin beta 1 remained uniformly distributed on the membrane even on fibronectin coating with little to no localization to FAs."
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"PLA2R1 Inhibits Differentiated Thyroid Cancer Proliferation and Migration via the FN1-Mediated ITGB1/FAK Axis."
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