IndraLab

Statements


ERBB decreases the amount of HCN4. 2 / 2
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"Three weeks after induction, reverse transcription-polymerase chain reaction analysis revealed that inhibition of NRG-1 and ErbB signaling (using AG1478) greatly enhanced the expression of HCN4, Tbx3, and Tbx2."

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"Inhibition of ErbB receptors with AG1478 significantly decreased the percentage of beating EBs; down-regulated the gene expressions of Nkx2.5, GATA4, MLC-2v, ANF, and alpha-actin; and concomitantly up-regulated the gene expressions of HCN4 and Tbx3 in a time dependent manner."