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ET-26 HCl inhibits KCNH2. 4 / 4
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"In the in vitro Langendorff preparation, none of the cardiac parameters were abnormal, and the hERG recordings showed that ET-26 HCl and etomidate inhibited the tail current of the hERG in a concentration dependent manner with an IC 50 of 742.51 muM and 263.60 muM, respectively."
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"In addition, the electrophysiology study indicated that ET-26 HCl and etomidate inhibited the hERG at a supra-therapeutic concentration."
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"The results suggest that etomidate and ET-26 HCl inhibited the tail current of the hERG in a concentration dependent manner, but the concentrations decreased the channel protein expression at a supra-therapeutic concentration or overdose, with an IC 50 of 263.60 muM and 742.51 muM, respectively."
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"The etomidate analogue, ET-26 HCl, inhibited the hERG current in a similar concentration dependent manner (XREF_FIG)."
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