IndraLab

Statements

BECN1 binds USP18. 5 / 5
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reach
"Since the expression of USP18 affects both autophagy and EGFR degradation (see below), we focused our analysis on the interaction of USP18 and BECN1 which is involved in both autophagy and EGFR degradation."
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"Strikingly, we found that there is interaction of endogenous BECN1 and USP18 after treatment with type I IFN."
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biogrid
No evidence text available
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"USP18 specifically interacts with BECN1."
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"The binding of USP18 with BECN1 was significantly reduced upon deletion of its BH3 domain (BECN1BH3D) and completely eliminated after further deletion of the CC domain (BECN1BH3D, CCDD), suggesting that both the BH3 and the CC domain of BECN1 are important for the interaction with USP18."
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