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SGK3 activates KCNQ1. 4 / 4
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"SGK3 has previously been shown to up-regulate KCNQ1 and KCNE1 [32], the other key K + channel involved in cardiac repolarization."
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"In Xenopus oocytes, the co-expression of SGK3 and KCNE1/KCNQ1 could up-regulate the KCNE1/KCNQ1-induced current, and the mutation of KCNE1/KCNQ1 led to Jervell and Lange–Nielsen syndrome, which is a disorder characterized by congenital profound sensorineural deafness, cardiac long QT syndrome, ventricular arrhythmias, and sudden cardiac death (Embark et al., 2003; Faridi et al., 2019)."
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"(Figure 2)In SGK3 and potassium transport, SGK3 can participate in up-regulating the activities of Kir2.1, Kir2.2, hERG, Kv7.1, BKCa, and Na /K - ATPase or indirectly enhance the potassium current induced by KCNA5 and Kv1.3 through the phosphorylation of Nedd4-2, participating in cardiac action potential, provide power for cardiac contraction, participate in renal proximal tubular membrane potential, maintain renal proximal tubular reabsorption function, and regulate neuronal excitability (Table 2)."
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"In vitro, the co-expression of SGK3 and KCNE1/KCNQ1(Kv7.1) in Xenopus oocytes could up-regulate the activity of the potassium channel KCNE1/KCNQ1 (Embark et al., 2003)."
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