IndraLab

Statements

Nigericin inhibits NLRP3. 10 / 10
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"We observed that loading LPS primed BMDC with BAPTA markedly attenuated multiple readouts of nigericin stimulated NLRP3 inflammasome signaling including total IL-1beta release (XREF_FIG), extracellular accumulation of p20 caspase-1 subunit and p17 mature IL-1beta (XREF_FIG), formation of ASC oligomers (XREF_FIG), and induction of pyroptotic propidium 2+ influx (XREF_FIG)."
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"To determine whether EOAA could inhibit the activation of the NLRP3 inflammasome induced by other stimulators, we activated the NLRP3 inflammasome with nigericin."
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"In order to identify the potential mechanisms, we further revealed that nigericin administration reversed the neuroprotective effect of melatonin by promoting NLRP3 inflammasome activation."
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"However, ASC oligomerization is necessary for all agonist induced NLRP3 inflammasome activation, so we speculate that Icariside I does not directly target ASC to exacerbate ATP or nigericin induced NLRP3 inflammasome activation."
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"Importantly, the additional presence of glycine to attenuate cell lysis did not modulate the effects of the lanthanides on nigericin stimulated NLRP3 inflammasome signaling and IL-1beta export (XREF_FIG)."
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"We confirmed previously reported observations that pre-treatment of LPS primed myeloid cells with 2-APB prior to stimulation by nigericin (or ATP) completely suppresses all indices of the activated NLRP3 signaling cascade."
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"Nigericin, known as an agonist of NLRP3 inflammasome-mediated pyroptosis, reversed the effects of eleutheroside E. Eleutheroside E prevented HAHI and inhibited inflammation and pyroptosis via the NLRP3/caspase-1 signalling pathway."
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"MCC950 and Nigericin sodium salt (Nig) were used to inhibit or promote the activation of NLRP3 inflammasome pharmacologically, respectively."
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"Suppression of nigericin stimulated NLRP3 inflammasome signaling by BAPTA and 2-APB can be dissociated from perturbation of Ca 2+ signaling."
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"To demonstrate the effect of ADAM10 depletion was specific to Hla induced cell death and not generally suppressive of NLRP3 activation, siRNA transfected cells were also treated with nigericin, a pore forming toxin known to activate NLRP3, and assessed for cell death [XREF_BIBR]."
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