IndraLab

Statements

ATXN3 activates Ubiquitin. 8 / 9
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"Through this process, ataxin-3 can facilitate substrate entry into the proteasome, as well as mediate other ubiquitin dependent pathways."
28918024
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"However, inactivation of ATX3 only increased the accumulation of K63‐Ub at sites of DNA damage."
31613024
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"With respect to linkage-specific Ub species, total and LMW K63-Ub were increased by 25% in SCA3 NPCs compared to CTRL NPCs upon autophagy inhibition (Figure 6C)."
37122622
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"As reported previously, ataxin-3 (Q22) deubiquitinates K63 linked ubiquitin chains and promotes the appearance of smaller ubiquitin chains over time."
22970133
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"Whether ataxin 3 produces unanchored ubiquitin chains and activates HDAC6 remains to be tested."
24035499
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"Mono-ubiquitination of ataxin-3, which is enhanced by proteotoxic stress, increases its ubiquitin hydrolase activity XREF_BIBR."
22970133
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"CHIP associated Ataxin-3 promotes the efficacy of Ub labeling on CHIP substrates, probably by preventing the lengthy Ub chain extension on CHIP substrates."
23329792
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"Ataxin-3 containing the 71Q expansion associated with RNF8 mediated ubiquitin chains with similar efficiency as wild-type ataxin-3 (10Q), indicating that the expanded polyQ stretch does not affect the ubiquitin binding activity of ataxin-3."
27731380