IndraLab

Statements

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"In vivo real time K + flux measurements and concurrent patch-clamp data on Jurkat cells revealed that both TRESK and K v 1.3 mediate AVD in the intrinsic apoptosis pathway, yet TRESK is transiently upregulated by apoptotic stimulus (staurosporine) and then completely inactivated in a half of hour, causing a strong membrane depolarization, whereas the K v 1.3 contribution to the K + efflux was more constant in time [XREF_BIBR]."
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"In cultured neurons, the downregulation of TRESK mRNA expression induced apoptosis of dorsal spinal cord neurons."
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"TRESK contributes to pain threshold changes by mediating apoptosis via MAPK pathway in the spinal cord."
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"Therefore, we investigated whether TRESK mediates inflammation and apoptosis by MAPK pathway in the spinal cord of NP rats."
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"Further, TRESK can relieve mechanical pain and reduce inflammatory response and apoptosis."
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"TRESK also contributes to the development of neuropathic pain by regulating inflammation and apoptosis mediated by MAPK signaling [66]."
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