IndraLab

Statements

USP48 inhibits RELA. 3 / 3
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"Our observations that endogenous p65 level is required for normal synapse formation but USP48 overexpression strikingly inhibits synapse formation in a p65-dependent manner can be explained by USP48-dependent up-regulation of a subset of NF-κB target genes, including proBDNF and Caspase-3."
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"Another study on USP48-mediated p65/p50 regulation conducted in retinal pigment epithelial cells unveils that knockdown of USP48 causes destabilization of both cytoplasmic and nuclear p65 and downregulates NF-κB activity despite the interaction between USP48 and p65 (59)."
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"Although USP48 stabilizes NF-κB p65 in HeLa cells via the removal of the K48-linked polyubiquitin chain [158], gene silencing of Usp48 increases nuclear NF-κB p65 protein in cultured retinal pigment epithelial cells without any stimulation [159]."
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